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Conclusion and Future Perspectives Current research shows that MO exerts its multiple immune-related effects primarily through directly eliminating pathogens or modulating the balance of pro- and anti-inflammatory mediators released from various kinds of immune cells by regulating the activity of signaling pathways, such as the canonical NF-B pathway (Figure 1)

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The recombinant GST-CTD used in these assays was unphosphorylated, as our previous results demonstrated that ORF24 co-immunoprecipitates only hypophosphorylated Pol II from mammalian cells (Davis et al., 2015)

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